The ribosomal DNA landscape of mammalian muscle during acute and chronic physiological stress
Daniel Vaughan, Nathanael Wood, Robert A. E. Seaborne
The paper examines rDNA copy number and methylation changes in aged vs young mice, finding significant reductions in methylation and a strong correlation with copy number, but no similar changes in muscle under acute stress.
bioRxiv · Aug 18, 2026 · PreprintPhysiology