Robert A. E. Seaborne

The paper examines rDNA copy number and methylation changes in aged vs young mice, finding significant reductions in methylation and a strong correlation with copy number, but no similar changes in muscle under acute stress.

This study examines how NR supplementation and HIIT affect skeletal muscle epigenetic aging, finding opposing effects on epigenetic age acceleration across different clocks.

This study identifies an inflammatory myofiber state in ICU-acquired weakness linked to altered myosin dynamics through integrated single-fiber multi-omics analysis.

This paper introduces SMPFO, a method combining fluorescence assays and proteome profiling to study skeletal muscle, revealing reduced myofiber subtype divergence in nemaline myopathy.

This study investigates altered myosin super-relaxation and energy metabolism in type II diabetes using muscle biopsies and proteomic analyses, finding increased super-relaxation and reduced ATP demand.

This study identifies sources of skeletal muscle fiber heterogeneity beyond myosin heavy chains using transcriptomic and proteomic data from human muscle fibers.

This study tests Mavacamten's ability to rescue metabolic dysregulation in nebulin-deficient muscle, finding it effective in vitro but ineffective in vivo for reversing the proteome changes.

This study integrates multi-OMIC data from 12 cohorts to identify exercise-specific molecular signatures and gene regulatory patterns in human skeletal muscle.

The paper identifies an association between ribosomal DNA copy number and body mass in humans and rats, showing it relates to growth rate and BMI but not obesity.

This study examines changes in skeletal muscle myosin metabolic states during hibernation in different mammals, finding reduced ATP consumption and potential mechanisms for energy conservation.

This study shows that genetic variation in rDNA affects epigenetic states and rRNA expression in mice and humans, with species-specific patterns observed.

Resistance training reduces methylation at 63% of mtDNA CpG sites in older males, mimicking a youthful methylome signature and enhancing mitochondrial function.