Structure-aware protein function prediction at isoform resolution
Felicia Jiang, Runhao Zhao, Feng Liang, Xiang Zhao, Taoyong Cui, Zhenchao Tang, Y S Zhang, Danyu Chen, minghao Xu, Yi Shuai, Tianli Luo, Xiangeng Wang, Chenchen Xu, Ziwei Wang, Weixin Zeng, , Xin Wang
This study develops a framework for predicting protein function and domain annotation at isoform resolution using structural and sequence data, showing strong performance in benchmark tests and capturing domain changes across isoforms.
bioRxiv · Jun 7, 2026 · PreprintCancer Biology