Alternative splicing expands and remodels the breast cancer proteoform landscape
Tao Jiang, Dengwang Chen, Xiangeng Wang, Hao Hao, Yinghan Zhang, Runhao Zhao, Feng Liang, Taoyong Cui, Zhenchao Tang, Tianli Luo, Yi Shuai, Minghao Xu, Chenchen Xu, Jia Xu, Wentao Zhang, , Xin Wang
The paper develops 3DisoGalaxy to study alternative splicing in breast cancer, finding that many transcripts produce translation-supported proteins and that functional divergence is concentrated in specific regions.
bioRxiv · Aug 26, 2026 · PreprintCancer Biology