Combination of engineered cell type-specific promoters and a high-efficiency AAV capsid restores hearing in adult DFNB1 mice model with demonstrated safety in nonhuman primate
Shao Wei Hu, Cheng Ye, Guannan Geng, Yicheng Zeng, Yihan Bao, Sen Zhang, Chong Cui, Yingting Zhang, Dan Mu, Daqi Wang, Xintai Fan, Ziting Chen, Biyun Zhu, Shuang Han, Hongxing Wang, , Yilai Shu
This paper demonstrates hearing restoration in adult DFNB1 mice using engineered promoters and an AAV capsid, with safety confirmed in nonhuman primates.
bioRxiv · Apr 18, 2026 · PreprintGenetics