Yilai Shu

This paper demonstrates hearing restoration in adult DFNB1 mice using engineered promoters and an AAV capsid, with safety confirmed in nonhuman primates.

This study uses base editing to correct a mutation causing hearing loss in a humanized mouse model, restoring hearing function and gene expression.

This study uses genome editing in adult mice with a MIR96 mutation to restore hearing, showing efficacy that improves with earlier intervention.

This study evaluates the efficacy and safety of AAV1-hOTOF gene therapy in mice and non-human primates for treating DFNB9 hearing loss.