Cancer BiologybioRxivPreprint
Dark selection for JAK/STAT-inhibitor resistance in chronic myelomonocytic leukemia
Artem Kaznatcheev, David Robert Grimes, Robert Vander Velde…·David Basanta
The paper challenges the classic U-shape model of resistance by proposing alternative population-level models for ruxolitinib resistance in CMML and explores the role of oxygen and cytokine signaling in resistance dynamics.
DOI 10.1101/211151