Basigin Links Altered Skeletal Stem Cell Lineage Dynamics with Glucocorticoid-induced Bone Loss and Impaired Angiogenesis
Thomas H. Ambrosi, David Morales, Kun Chen, Ethan J. Hunt, Kelly C. Weldon, Amber N Maifeld, Fernando Sigler Chávez, Yuting Wang, Liming Zhao, Luke Wang, Matthew Philip Murphy, Amin Cressman, Erika E. Wheeler, Augustine M. Saiz, Jonathan Kent Leach, , Nancy E. Lane
This study identifies Basigin's role in GC-induced bone loss and impaired angiogenesis by linking altered skeletal stem cell dynamics to vascular dysfunction, showing that anti-Basigin therapy can reverse these effects.
Nature Communications · Aug 15, 2025Peer-reviewedCell Biology