Nancy E. Lane

The paper examines the association between skeletal muscle gene expression and knee osteoarthritis in older adults using bulk RNA sequencing from the SOMMA study.

The paper identifies miRNA-gene regulatory networks associated with VO2peak in older adults using RNA sequencing and pathway analysis.

This study identifies Basigin's role in GC-induced bone loss and impaired angiogenesis by linking altered skeletal stem cell dynamics to vascular dysfunction, showing that anti-Basigin therapy can reverse these effects.

The paper identifies miRNA signatures associated with VO2peak variation in older adults using serum small RNA sequencing and statistical analysis.

This paper identifies CCN3 as a brain-derived hormone that promotes bone mass in lactating females by compensating for estrogen loss and supporting skeletal stem cells.

This study identifies genetic determinants of hip joint space width and finds they have opposing causal effects on hip osteoarthritis risk through distinct mechanisms.

This study produces and characterizes a plant-based PTH-Fc fusion protein that shows similar potency to PTH (1-34) in binding and activating PTH1R, making it suitable for space medicine applications.

The paper shows that gut microbiome uniqueness increases with age and predicts survival in humans.

This paper conducts a genome-wide meta-analysis of chronic back pain in 158,025 individuals, identifying three genetic loci associated with the condition.