Author

Dean Swinden

University of Cambridge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:machine learning (classical)· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Christine RowleyiD· 2 shared Dmytro ShepiloviD· 2 shared Edward C. HardingiD· 2 shared Florian T. MerkleiD· 2 shared Giovanna R. MallucciiD· 2 shared Heather SmithiD· 2 shared Hsiao‐Jou Cortina CheniD· 2 shared Adrian J. ButcheriD· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersNeuroscience

Christine RowleyORCID

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Author profile →

4 papers

Recent·Most cited

Unbiased preclinical phenotyping reveals neuroprotective properties of pioglitazone

Edward C. Harding, Hsiao‐Jou Cortina Chen, Dmytro Shepilov, S. Zhang, Christine Rowley, Iman D. Mali, Jiahui Chen, Natasha M. Stewart, Dean Swinden, Sam J. Washer, Andrew R. Bassett, Florian T. Merkle

The paper uses a mouse prion model and machine learning to identify neuroprotective effects of pioglitazone in neurodegenerative disease.

bioRxiv · Aug 30, 2024 · PreprintNeuroscience

Metformin acts directly in the brain to slow features of neurodegeneration.

Edward C. Harding, Hsiao‐Jou Cortina Chen, Dmytro Shepilov, Marc Welzer, Viviana Macarelli, Alix Schwiening, Christine Rowley, Sanya Aggarwal, Dean Swinden, Deborah Kronenberg‐Versteeg, Florian T. Merkle

This study shows metformin can slow neurodegeneration features in mice, even in metabolically healthy individuals, by acting directly in the brain.

bioRxiv · Jul 18, 2023 · PreprintNeuroscience

Trazodone rescues dysregulated synaptic and mitochondrial nascent translatomes in prion neurodegeneration

Héctor Albert‐Gascó, Heather Smith, Beatriz Alvarez‐Castelao, Dean Swinden, Mark Halliday, Sudha Janaki‐Raman, Adrian J. Butcher, Giovanna R. Mallucci

This study shows trazodone restores synaptic and mitochondrial protein synthesis in prion-diseased mice, reversing neurodegeneration through translational modulation.

bioRxiv · Jun 5, 2023 · PreprintNeuroscience

ASO targeting temperature-controlled RBM3 poison exon splicing prevents neurodegeneration in vivo

Marco Preußner, Heather Smith, Min Zhang, Daniel Hughes, Ann‐Kathrin Emmerichs, Silvia Scalzitti, Diego Peretti, Dean Swinden, Alexander Neumann, Tom Haltenhof, Giovanna R. Mallucci, Florian Heyd

Inducing cold shock protein RBM3 by modulating its alternative splicing at normothermia is neuroprotective in vivo.

bioRxiv · Oct 26, 2022 · PreprintMolecular Biology