High-dose oral pyrophosphate inhibits connective tissue calcification in Abcc6 null mice but affects bone structure
Ibtesam Rajpar, Nicholas Yancy, Jacob Beiriger, C. Shao, Syed Naqvi, Deana Mancuso, Fatemeh Niaziorimi, Ryan E. Tomlinson, Koen van de Wetering
This study shows that only very high oral doses of pyrophosphate inhibit ectopic calcification in Abcc6-/- mice, but these doses harm bone structure and are impractical for human use.
bioRxiv · Jul 16, 2025 · PreprintPathology