Cancer BiologybioRxivPreprint
Rac1 and CHK1 Converge on Abi-1 to Regulate DNA Repair Dependency and Treatment Response in Human Cancers
Yiheng Huang, Elizabeth C. McCulla, Jihan Park…·Weihua Zhou
This study identifies Abi-1-S323 phosphorylation as a biomarker for DNA repair states and treatment response in cancers, showing its role in regulating radiosensitivity through Rac1 and CHK1 signaling.
DOI 10.64898/2026.09.11.750952