Proteolysis targeting chimera extracellular vesicles for therapeutic development treating triple negative breast cancer
Nina Erwin, Umasankar De, Yufeng Xiao, Lei Wang, Chandra K. Maharjan, Xiaoshu Pan, Ding Zuo, Nikee Awasthee, Guangrong Zheng, Daiqing Liao, Weizhou Zhang, Mei He
This paper demonstrates that microfluidic droplet-based electroporation (microDES) enhances PROTAC drug delivery via extracellular vesicles, improving therapeutic efficacy and safety in a TNBC mouse model.
Journal of Extracellular Vesicles · Dec 1, 2025Peer-reviewedBioengineering