Mei He

This paper demonstrates that microfluidic droplet-based electroporation (microDES) enhances PROTAC drug delivery via extracellular vesicles, improving therapeutic efficacy and safety in a TNBC mouse model.

This study develops a microfluidic method to produce collagen microbeads for 3D cell culture and extracellular vesicle production, showing high throughput and cell compatibility.

The paper develops a scalable microfluidic electroporation system to load gRNA:Cas9 RNP complexes into extracellular vesicles, achieving effective gene therapy for hearing loss in a mouse model.

This study identifies miRNA biomarkers in plasma extracellular vesicles for noninvasive detection of AATD liver disease, achieving an AUC of 0.751 with a four-miRNA model.

This paper isolates exosomes from human perilymph to enable molecular diagnosis of sensorineural hearing loss by targeting sensory hair cells using myosin VII expression.