Generation of Genetically Identical Mammalian Oocytes from Parthenogenetic Double-Haploid Embryonic Stem Cells
Guowei Zou, Shu Wei, Yanyan Zhang, Dingrui Guo, Shuaipeng Li, Mei Hu, Juan Du, Wanchu Wang, Muhammad Ameen Jamal, Wandong Bao, Chikai Zhou, Xiaomin Kang, Shuhui Bian, Jiangwei Lin
This study generates genetically identical mammalian oocytes using parthenogenetic double-haploid embryonic stem cells and blastocyst complementation, producing viable and fertile mice with epigenetic defects.
bioRxiv · Apr 7, 2026 · PreprintDevelopmental Biology