Yanyan Zhang

This study shows that venetoclax resistance in AML creates a vulnerability to canonical pyroptosis, which can be targeted with DPP8/9 inhibitors and NLRP3 activators.

This study generates genetically identical mammalian oocytes using parthenogenetic double-haploid embryonic stem cells and blastocyst complementation, producing viable and fertile mice with epigenetic defects.

The paper shows that efficient reprogramming in SCNT occurs exclusively in the epiblast, enabling cloned mouse generation through a lineage-specific mechanism.

The paper identifies GvmR as a key regulator of guvermectin biosynthesis in Streptomyces, revealing its interactions with other regulators and pathways involved in precursor supply and energy synthesis.