Cancer BiologybioRxivPreprint
Adaptive Plasticity Tumor Cells Modulate MAPK-Targeting Therapy Response in Colorectal Cancer
Oscar Eduardo. Villarreal, Yixin Xu, Ha Tran…·Scott Kopetz
The paper identifies adaptive plasticity tumor (APT) cells that reduce response to MAPK inhibitors in colorectal cancer by increasing stemness and ASCL2 expression, and shows that targeting APT cells improves therapy efficacy.
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