BiochemistryeLifePeer-reviewed
Alzheimer's disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling
Katarzyna Marta Zoltowska, Utpal Das, Sam Lismont…·Lucía Chávez‐Gutiérrez
This study shows that human Aβ42 inhibits γ-secretase, leading to substrate accumulation and neuronal dysfunction, suggesting a feedback mechanism in Alzheimer's disease.
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