Author

Dora Barbosa

Department of Medicine, University of California, San Francisco, San Francisco, CA 94158, USA

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Beatrice GiniiD· 2 shared Paul Allegakoen· 2 shared Sarah Elmes· 2 shared Wei WuiD· 2 shared Carlos Gomez· 1 shared Collin M. Blakely· 1 shared D. Lucas Kerr· 1 shared Donghwa KimiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

Beatrice GiniORCID

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2 papers

Recent·Most cited

Actionable biological programs to enhance EGFR-targeted therapy response unveiled by single-cell lineage tracing in clinically relevant lung cancer models

Beatrice Gini, Whitney Tamaki, Johnny X. Yu, Dora Barbosa, Wei Wu, Yashar Pourmoghadam, Paul Allegakoen, Donghwa Kim, Sohit Miglani, Sarah Elmes, Victor R. Olivas, Hani Goodarzi, Trever Grant Bivona

This study uses single-cell lineage tracing and RNAseq to identify pre-existing resistant tumor subclones in lung cancer models and their transcriptional programs, revealing mechanisms of therapy resistance.

bioRxiv · May 19, 2025 · PreprintCancer Biology

CDK4 or CDK6 upregulation induces DNA replication stress and genomic instability to cause EGFR targeted therapy resistance in lung cancer

Beatrice Gini, Philippe Gui, Wei Wu, D. Lucas Kerr, Lisa Tan, Dora Barbosa, Victor Olivas, Paul Allegakoen, Carlos Gomez, Patrick R. Halliday, Sarah Elmes, Veronica Steri, Turja Chakrabarti, Trever G. Bivona, Collin M. Blakely

This study shows that CDK4/6 upregulation causes DNA replication stress and genomic instability, leading to resistance to EGFR inhibitors in lung cancer, and suggests combining CDK4/6 and EGFR inhibitors as a treatment.

bioRxiv · Mar 12, 2024 · PreprintCancer Biology