Dylan T. Garceau

Characterization of the knock-in AppSAA mouse model as a powerful tool for Alzheimer's disease preclinical research.

The paper characterizes the AppSAA knock-in mouse model, showing it recapitulates age-dependent Alzheimer's disease phenotypes and provides a tool for preclinical research.

MTHFR*677C>T produces distinct prodromal disease signatures in a mouse model of late-onset Alzheimer's disease

The paper shows that the MTHFR*677C>T variant in a mouse model of LOAD produces distinct transcriptional and proteomic signatures related to cerebrovascular and synaptic biology.

Humanized Klotho haplotypes cause widespread transcriptomic changes in mouse brain

This study shows that human KL haplotypes FC and VS cause widespread transcriptomic changes in mouse brains at 12 months old, affecting mitochondrial, ribosomal, and synaptic functions, and linking them to Alzheimer's Disease pathogenesis.

Trem2*R47H and reduced TREM2 expression both mimic human Alzheimer's disease signatures in mice

This study compares two mouse models of TREM2 variants, showing both mimic Alzheimer's disease signatures in similar biological domains.

Synaptic proteins that aggregate and degrade slower with aging accumulate in microglia

The paper identifies neuronal proteins that degrade slower with aging and accumulate in microglia, linking impaired synaptic protein turnover to age-related cognitive decline.

Characterizing Molecular and Synaptic Signatures in Mouse Models of Late-Onset Alzheimer's Disease Independent of Amyloid and Tau Pathology

This study characterizes molecular and synaptic changes in a mouse model of late-onset Alzheimer's disease under different dietary conditions, showing age-related brain volume loss and cognitive deficits.

In vivo validation of late-onset Alzheimer's disease genetic risk factors

The paper functionally validates 11 genetic risk variants for late-onset Alzheimer's disease using a mouse model and compares transcriptomic effects to human cohorts.

Metabolomics profiling reveals distinct, sex-specific signatures in the serum and brain metabolomes in the mouse models of Alzheimer's disease

The paper identifies sex-specific metabolomic differences in serum and brain of Alzheimer's disease mouse models, showing model-specific metabolic signatures that align with human APOE4 carriers.

Perivascular SPP1 Mediates Microglial Engulfment of Synapses in Alzheimers Disease Models

This study identifies SPP1 as a key mediator of microglial synaptic engulfment in Alzheimer's disease models, showing its role in neuroimmune interactions.

APOEϵ4 and exercise interact to influence systemic and cerebral risk factors for dementia

This study shows that APOEϵ4 genotype interacts with exercise to influence systemic and cerebral risk factors for dementia in mice, with sex-specific effects on metabolism, brain function, and aging.

Fibrillar Aβ causes profound microglial metabolic perturbations in a novel APP knock-in mouse model

This paper characterizes microglial metabolic changes in an APP knock-in mouse model of AD, finding lipid dysregulation and immunometabolic perturbations linked to fibrillar Aβ.

A novel systems biology approach to evaluate mouse models of late-onset Alzheimer’s disease

The paper introduces a NanoString nCounter Mouse AD panel to assess LOAD mouse models by correlating gene expression with human AD modules, showing strong correlation with RNA-Seq data.

APOEε3/ε4 and APOEε4/ε4 genotypes drive unique gene signatures in the cortex of young mice

This study identifies unique gene signatures in the cortex of young mice with APOEε3/ε4 and APOEε4/ε4 genotypes, showing distinct transcriptomic and functional differences.