Systemic hypoxia inhibits T cell response by limiting mitobiogenesis via matrix substrate-level phosphorylation arrest
A. Saragovi, I. Abramovitch, O. Toker, E. Arbib, I. Omar, E. Gottlieb, M. Berger
This study shows that systemic hypoxia impairs CD8+ T cell responses by inhibiting mitochondrial biogenesis, which can be rescued by TCA cycle re-stimulation or brief oxygen exposure.
bioRxiv · Mar 19, 2020Immunology