M. Berger

Metabolic Reprogramming Driven by Ant2 -Targeting Augments T-Cell Function and Anti-Tumor Immunity

This study shows that Ant2 deficiency enhances T-cell function and anti-tumor immunity by altering mitochondrial metabolism and metabolic reprogramming.

In situ investigation of extracellular vesicles in viscous formulations: interplay of nanoparticle transport and nanorheology through interferometric light microscopy analysis

This study introduces a pipeline using interferometric light microscopy to analyze extracellular vesicles in viscous media, characterizing their transport and the local viscosity of complex fluids.

Structural basis for translation inhibition 1 by the glycosylated antimicrobial peptide Drosocin from Drosophila melanogaster

This study reveals how O-glycosylation of drosocin affects its interaction with the ribosome, inhibiting translation by trapping RF1 in the exit tunnel.

Enhanced methionine cycle suppresses naïve CD8+ T-cell maturation

This study identifies an accelerated methionine cycle in immature CD8+ T cells that suppresses their maturation and immune response, showing that inhibiting the cycle promotes maturation and immune recovery.

Robust replication initiation from coupled homeostatic mechanisms

This paper develops a mathematical model showing that coupled titration and activation mechanisms of DnaA ensure robust replication initiation in E. coli across all growth rates.

S6K1 phosphorylates Cdk1 and MSH6 to regulate DNA repair.

This study identifies S6K1's role in DNA repair by phosphorylating Cdk1 and MSH6, showing its impact on cell cycle arrest and mismatch repair in breast cancer.

Ethanol-guided behavior in Drosophila larvae

This study investigates ethanol-guided behavior in Drosophila larvae, finding attraction to moderate ethanol concentrations and increased mortality at higher concentrations, with ethanol also serving as a learning signal.

Cellular water analysis in T cells reveals a switch from metabolic water gain to water influx

This study uses a novel method to analyze water content in T cells and finds a shift from metabolic water gain to extracellular water influx during cell growth.

Systemic hypoxia inhibits T cell response by limiting mitobiogenesis via matrix substrate-level phosphorylation arrest

This study shows that systemic hypoxia impairs CD8+ T cell responses by inhibiting mitochondrial biogenesis, which can be rescued by TCA cycle re-stimulation or brief oxygen exposure.