Author

I. Omar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:metabolomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Saragovi· 2 shared E. Gottlieb· 2 shared M. Berger· 2 shared O. Toker· 2 shared A. Drori· 1 shared A. R. Harrington· 1 shared A. Swisa· 1 shared B. Ramms· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersImmunology

A. Saragovi

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Enhanced methionine cycle suppresses naïve CD8+ T-cell maturation

A. Saragovi, X. Zheng, I. Abramovich, L. Cohen-Daniel, L. Zhuoning, H. Raifer, I. Omar, A. Swisa, M. Kuchersky, A. Drori, F. Marini, O. Toker, R. Somech, C. Schmidl, R. C. Hendrickson, , M. Berger

This study identifies an accelerated methionine cycle in immature CD8+ T cells that suppresses their maturation and immune response, showing that inhibiting the cycle promotes maturation and immune recovery.

bioRxiv · Aug 16, 2022 · PreprintImmunology

Systemic LSD1 inhibition prevents aberrant remodeling of metabolism in obesity

B. Ramms, D. P. Pollow, H. Zhu, C. Nora, A. R. Harrington, I. Omar, P. Gordts, M. Wortham, M. Sander

This study shows that systemic LSD1 inhibition reduces obesity-related metabolic issues like NAFLD and improves insulin sensitivity in mice without affecting lean mice.

bioRxiv · Nov 25, 2021Physiology

Systemic hypoxia inhibits T cell response by limiting mitobiogenesis via matrix substrate-level phosphorylation arrest

A. Saragovi, I. Abramovitch, O. Toker, E. Arbib, I. Omar, E. Gottlieb, M. Berger

This study shows that systemic hypoxia impairs CD8+ T cell responses by inhibiting mitochondrial biogenesis, which can be rescued by TCA cycle re-stimulation or brief oxygen exposure.

bioRxiv · Mar 19, 2020Immunology