E. Gottlieb

Metabolic Reprogramming Driven by Ant2 -Targeting Augments T-Cell Function and Anti-Tumor Immunity

This study shows that Ant2 deficiency enhances T-cell function and anti-tumor immunity by altering mitochondrial metabolism and metabolic reprogramming.

Fatty liver-mediated glycine restriction impairs glutathione synthesis and causes hypersensitization to acetaminophen

This study shows fatty liver reduces glycine, impairing glutathione synthesis and increasing sensitivity to acetaminophen toxicity in mice.

Population level genetic memory of prior metabolic adaptation in E. coli

This study shows E. coli maintains genetic memory of prior metabolic adaptations, enabling rapid re-adaptation to consume butyrate after resource exhaustion.

Enhanced methionine cycle suppresses naïve CD8+ T-cell maturation

This study identifies an accelerated methionine cycle in immature CD8+ T cells that suppresses their maturation and immune response, showing that inhibiting the cycle promotes maturation and immune recovery.

A multiomics comparison of weight loss interventions shows the distinct effects of bariatric surgery and intermittent fasting on hepatic metabolism

This study compares bariatric surgery and intermittent fasting in rats, showing they affect hepatic metabolism differently through distinct metabolic pathways.

Sexual deprivation induces a CRF independent stress response and decreases resistance to stressors in Drosophila via a subpopulation of Neuropeptide F receptor-expressing neurons

This study shows that sexual deprivation in Drosophila increases stress sensitivity and arousal through a specific subset of Neuropeptide F receptor-expressing neurons, independent of CRF-like pathways.

Host autophagy mediates organ wasting and nutrient mobilization for tumor growth

The paper shows that host autophagy drives organ wasting and nutrient mobilization to support tumor growth in Drosophila.

Cellular water analysis in T cells reveals a switch from metabolic water gain to water influx

This study uses a novel method to analyze water content in T cells and finds a shift from metabolic water gain to extracellular water influx during cell growth.

Systemic hypoxia inhibits T cell response by limiting mitobiogenesis via matrix substrate-level phosphorylation arrest

This study shows that systemic hypoxia impairs CD8+ T cell responses by inhibiting mitochondrial biogenesis, which can be rescued by TCA cycle re-stimulation or brief oxygen exposure.