Author

E. Ayan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 8 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Assay:structural biology· 7 Research Focus:protein folding & dynamics· 4 Research Focus:protein structure prediction· 4 Assay:protein structure· 3 Approach:statistical model· 2 Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

E. Destan· 9 shared H. Demirci· 8 shared F. B. Ertem· 7 shared A. Shafiei· 5 shared H. Ciftci· 5 shared M. Liang· 5 shared O. Guven· 5 shared R. G. Sierra· 5 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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9 shared papersBiophysics

E. Destan

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

X-ray Crystallographic and Hydrogen Deuterium Exchange Studies Confirm Alternate Kinetic Models for Homolog Insulin Monomers

E. Ayan, M. Turk, O. Tatli, S. Bostan, E. Telek, B. Dingiloglu, B. Z. Dogan, M. I. Alp, A. Kati, G. Dinler Doganay, H. Demirci

The paper uses X-ray crystallography and hydrogen-deuterium exchange to study insulin analog dynamics, showing faster deuterium exchange and structural insights into modified insulin monomers.

bioRxiv · Apr 16, 2024Biophysics

4D Crystallography Captures Transient IF1-Ribosome Dynamics in Translation Initiation

I. Yapici, E. H. Dao, S. Yokoi, E. Destan, E. Ayan, A. Shafiei Kamel, F. B. Ertem, C. Kulakman, M. Yilmaz, B. Tosun, H. Ciftci, A. Kepceoglu, J. A. Johnson, O. Guven, A. Ergul, , H. DeMirci

This study uses 4D crystallography to capture transient dynamics of IF1 binding to the 30S ribosomal subunit, revealing allostery and interactions during translation initiation.

bioRxiv · Oct 27, 2023 · PreprintBiophysics

Ambient Temperature Bacterial Large Ribosomal Subunit Structure Enabled by Serial Femtosecond X-ray Crystallography

B. Tosun, Y. Rao, E. Destan, E. H. Dao, F. B. Ertem, M. Yilmaz, I. Yapici, M. Gul, E. Ayan, J. A. Johnson, A. Shafiei, C. Kulakman, B. Hayes, M. Liang, C. H. Yoon, , H. DeMirci

This study determines the structure of the 50S ribosomal subunit from Thermus thermophilus at ambient temperature using serial femtosecond X-ray crystallography, revealing new dynamics and antibiotic binding sites.

bioRxiv · Oct 24, 2023 · PreprintBiophysics

Comparative Study of High-resolution LysB29(Nε-myristoyl) des(B30) Insulin Structures Display Novel Dynamic Causal Interrelations in Monomeric-Dimeric Motions

E. Ayan, E. Destan, A. Kepceoglu, H. Ciftci, A. Kati, H. DeMirci

The paper compares high-resolution crystal structures of insulin detemir to identify dynamic conformational changes and their implications for oligomeric equilibrium.

bioRxiv · Nov 19, 2022Biophysics

Rapid and Efficient Ambient Temperature X-ray Crystal Structure Determination at Turkish Light Source

M. Gul, E. Ayan, E. Destan, J. A. Johnson, A. Shafiei, A. Kepceoglu, M. Yilmaz, F. B. Ertem, I. Yapici, B. Tosun, N. Baldir, N. Tokay, Z. Nergiz, G. Karakadioglu, S. S. Paydos, , H. DeMirci

The paper introduces a plate-reader module for rapid ambient temperature X-ray crystallography at a home source and reports the first lysozyme structure determined at Turkish DeLight.

bioRxiv · Oct 12, 2022 · PreprintBiophysics

Cryogenic X-ray crystallographic studies of biomacromolecules at Turkish Light Source: Turkish DeLight

N. Atalay, E. K. Akcan, M. Gul, E. Ayan, E. Destan, F. B. Ertem, N. Tokay, B. Cakilkaya, Z. Nergiz, G. Karakadioglu, A. Kepceoglu, I. Yapici, B. Tosun, N. Baldir, G. Yildirim, , Kati

The paper describes the setup and application of a new X-ray crystallography facility in Turkey for structural analysis of biomacromolecules using lysozyme as a model.

bioRxiv · Sep 3, 2022Biophysics

Cooperative Allostery and Structural Dynamics of Streptavidin at Cryogenic- and Ambient-temperature

E. Ayan, B. Yuksel, E. Destan, F. B. Ertem, G. Yildirim, M. Eren, O. M. Yefanov, A. Barty, A. Tolstikova, G. K. Ketawala, S. Botha, E. H. Dao, B. Hayes, M. Liang, M. H. Seaberg, , H. DeMirci

The paper presents two apo-streptavidin structures at different temperatures and reveals cooperative allostery through water-mediated interactions.

bioRxiv · Sep 23, 2021Biophysics

Structural Insights into Bifunctional Thaumarchaeal Crotonyl-CoA Hydratase and 3-Hydroxypropionyl-CoA Dehydratase from Nitrosopumilus maritimus

E. Destan, B. Yuksel, B. B. Tolar, E. Ayan, S. Deutsch, Y. Yoshikuni, S. Wakatsuki, C. A. Francis, H. DeMirci

This study presents the first high-resolution crystal structure of a bifunctional enzyme involved in the 3HP/4HB cycle in Nitrosopumilus maritimus, revealing its dual catalytic activities.

bioRxiv · Sep 22, 2021 · PreprintBiochemistry

Structural insight into host plasma membrane association and assembly of HIV-1 Matrix protein

H. Ciftci, H. Tateishi, K. Koiwai, R. Koga, K. Anraku, K. Monde, C. Dag, E. Destan, B. Yuksel, E. Ayan, G. Yildirim, M. Yigin, F. B. Ertem, A. Shafiei, O. Guven, , H. DeMirci

This study presents crystal structures of HIV-1 MA domain bound to IP6, revealing its binding mode and interaction with PIP2, providing insights into virion assembly.

bioRxiv · Feb 21, 2021 · PreprintMicrobiology

Near-Physiological-Temperature Serial Femtosecond X-ray Crystallography Reveals Novel Conformations of SARS-CoV-2 Main Protease Active Site for Improved Drug Repurposing

S. Durdagi, C. Dag, B. Dogan, M. Yigin, T. Avsar, C. Buyukdag, I. Erol, F. B. Ertem, S. Calis, G. Yildirim, M. Orhan, O. Guven, B. Aksoydan, E. Destan, K. Sahin, , Sn

The paper determines two apo structures of SARS-CoV-2 main protease at near-physiological temperature using SFX and uses molecular simulations to analyze inhibitor binding for drug repurposing.

bioRxiv · Sep 9, 2020Biophysics