R. G. Sierra

The paper uses XFEL crystallography to observe conformational changes in an enzyme during catalysis, revealing ionization-linked dynamics that control catalytic activity.

The paper detects a geminate photoproduct of bovine cytochrome c oxidase using time-resolved serial femtosecond crystallography, revealing the ligand dissociation trajectory and protein dynamics.

This study reveals the structural differences between the oxidized O state and the metastable OH state of cytochrome c oxidase using spectroscopy and crystallography, showing how Y244's protonation state affects proton translocation.

This study uses temperature-jump X-ray crystallography to observe atomic-scale protein motions in lysozyme, showing how vibrations evolve into functional movements and how inhibitors alter these dynamics.

This paper investigates the structural and dynamic mechanisms of CO2 fixation by ECRs, revealing inter-subunit coupling that enables fast catalytic activity.

The paper presents two apo-streptavidin structures at different temperatures and reveals cooperative allostery through water-mediated interactions.

This study presents crystal structures of HIV-1 MA domain bound to IP6, revealing its binding mode and interaction with PIP2, providing insights into virion assembly.

The paper determines two apo structures of SARS-CoV-2 main protease at near-physiological temperature using SFX and uses molecular simulations to analyze inhibitor binding for drug repurposing.

This study uses mix-and-inject XFEL crystallography to observe conformational changes in isocyanide hydratase during catalysis, showing how cysteine modification affects enzyme dynamics and function.

This study compares serial X-ray crystallography and MicroED for determining structures from small macromolecular crystals, highlighting their strengths and challenges.

This study uses serial femtosecond X-ray crystallography to analyze HIV-1 Gag MA-IP6 microcrystals at ambient temperature, achieving high-resolution diffraction data.

This study examines aminoglycoside interactions with the bacterial 30S ribosome at ambient and cryogenic temperatures, revealing temperature-sensitive conformational changes and new structural states.

The paper reports an ambient-temperature X-ray crystal structure of the Thermus thermophilus 30S ribosomal decoding complex, showing consistency with cryogenic structures but with minor conformational variations.