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14 papers
Recent·Most cited
I. Yapici, E. H. Dao, S. Yokoi, E. Destan, E. Ayan, A. Shafiei Kamel, F. B. Ertem, C. Kulakman, M. Yilmaz, B. Tosun, H. Ciftci, A. Kepceoglu, J. A. Johnson, O. Guven, A. Ergul, , H. DeMirci
This study uses 4D crystallography to capture transient dynamics of IF1 binding to the 30S ribosomal subunit, revealing allostery and interactions during translation initiation.
bioRxiv · Oct 27, 2023 · PreprintBiophysics
B. Tosun, Y. Rao, E. Destan, E. H. Dao, F. B. Ertem, M. Yilmaz, I. Yapici, M. Gul, E. Ayan, J. A. Johnson, A. Shafiei, C. Kulakman, B. Hayes, M. Liang, C. H. Yoon, , H. DeMirci
This study determines the structure of the 50S ribosomal subunit from Thermus thermophilus at ambient temperature using serial femtosecond X-ray crystallography, revealing new dynamics and antibiotic binding sites.
bioRxiv · Oct 24, 2023 · PreprintBiophysics
I. Ishigami, R. G. Sierra, Z. Su, A. Peck, C. Wang, F. Poitevin, S. Lisova, B. Hayes, F. R. Moss, S. Boutet, R. E. Sublett, C. H. Yoon, S.-R. Yeh, D. L. Rousseau
This study reveals the structural differences between the oxidized O state and the metastable OH state of cytochrome c oxidase using spectroscopy and crystallography, showing how Y244's protonation state affects proton translocation.
bioRxiv · Mar 20, 2023 · PreprintBiophysics
B. Hayes, P. Zhu, M. Wang, C. Pfeifer, Y. Xia, S. Phan, J. Andrechak, J. Du, M. Tobin, A. Anlas, L. Dooling, J. Irianto, M. Lampson, D. Discher
The paper uses live-cell ChReporters to show that Myosin-II suppression in confined mitosis increases heritable chromosome loss, independent of spindle assembly checkpoint in 3D and 2D.
bioRxiv · Feb 25, 2023 · PreprintCell Biology
C. Martyn, B. Hayes, D. Lauko, E. Mithun, G. Castaneda, A. Bosco-Lauth, A. Kistler, K. Pollard, S. Chou
The paper uses metatranscriptomic analysis of Ixodes pacificus ticks to identify novel viruses and virus-like elements, revealing their potential roles in tick physiology and public health.
bioRxiv · Aug 17, 2022 · PreprintMicrobiology
H. Demirci, Y. Rao, G. M. Stoffel, B. Vögeli, K. Schell, A. Gomez, A. Batyuk, C. Gati, R. G. Sierra, M. S. Hunter, E. H. Dao, H. I. Ciftci, B. Hayes, F. Poitevin, P. Li, , S. Wakatsuki
This paper investigates the structural and dynamic mechanisms of CO2 fixation by ECRs, revealing inter-subunit coupling that enables fast catalytic activity.
bioRxiv · Feb 23, 2022 · PreprintBiophysics
A. Radkov, A. L. Sapiro, S. Flores, C. Henderson, H. Saunders, R. Kim, S. Massa, S. Thompson, C. Mateusiak, J. Biboy, Z. Zhao, L. M. Starita, W. Hatleberg, W. Vollmer, A. B. Russell, , S. Chou
This study identifies functional determinants of Tae1, a bacterial T6SS amidase toxin, showing that its antimicrobial potency depends on substrate topology and cellular context.
bioRxiv · Feb 15, 2022Biochemistry
E. Ayan, B. Yuksel, E. Destan, F. B. Ertem, G. Yildirim, M. Eren, O. M. Yefanov, A. Barty, A. Tolstikova, G. K. Ketawala, S. Botha, E. H. Dao, B. Hayes, M. Liang, M. H. Seaberg, , H. DeMirci
The paper presents two apo-streptavidin structures at different temperatures and reveals cooperative allostery through water-mediated interactions.
bioRxiv · Sep 23, 2021Biophysics
M. Vashisth, D. Discher, S. Cho, J. Irianto, Y. Xia, M. Wang, B. Hayes, F. Jafarpour, A. Liu, R. G. Wells
The paper identifies scaling relationships between genes in cancer data, finding LMNB1 correlates with poor prognosis while fibrosis markers predict better survival.
bioRxiv · Feb 25, 2021 · PreprintCancer Biology
S. Durdagi, C. Dag, B. Dogan, M. Yigin, T. Avsar, C. Buyukdag, I. Erol, F. B. Ertem, S. Calis, G. Yildirim, M. Orhan, O. Guven, B. Aksoydan, E. Destan, K. Sahin, , Sn
The paper determines two apo structures of SARS-CoV-2 main protease at near-physiological temperature using SFX and uses molecular simulations to analyze inhibitor binding for drug repurposing.
bioRxiv · Sep 9, 2020Biophysics
M. DasGupta, D. Budday, S. H. P. de Oliveira, P. Madzelan, D. Marchany-Rivera, J. Seravalli, B. Hayes, R. G. Sierra, S. Boutet, M. Hunter, R. Alonso-Mori, A. Batyuk, J. Wierman, A. Lyubimov, A. S. Brewster, , M. A. Wilson
This study uses mix-and-inject XFEL crystallography to observe conformational changes in isocyanide hydratase during catalysis, showing how cysteine modification affects enzyme dynamics and function.
Proceedings of the National Academy of Sciences · Dec 4, 2019Peer-reviewedBiochemistry
M. E. O'Sullivan, F. Poitevin, R. G. Sierra, C. Gati, E. H. Dao, Y. Rao, F. Aksit, H. Ciftci, N. Corsepius, R. Greenhouse, B. Hayes, M. S. Hunter, M. Liang, A. McGurk, P. Mbgam, , H. DeMirci
This study examines aminoglycoside interactions with the bacterial 30S ribosome at ambient and cryogenic temperatures, revealing temperature-sensitive conformational changes and new structural states.
bioRxiv · Jul 19, 2018Biophysics
E. H. Dao, F. Poitevin, R. G. Sierra, C. Gati, Y. Rao, H. I. Ciftci, F. Aksit, A. McGurk, T. Obrinski, P. Mgbam, B. Hayes, C. de Lichtenberg, F. Pardo-Avila, N. Corsepius, L. Zhang, , H. DeMirci
The paper reports an ambient-temperature X-ray crystal structure of the Thermus thermophilus 30S ribosomal decoding complex, showing consistency with cryogenic structures but with minor conformational variations.
bioRxiv · Mar 9, 2018Biophysics
B. D. Ross, B. Hayes, M. C. Radey, X. Lee, T. Josek, J. Bjork, D. Neitzel, S. Paskewitz, S. Chou, J. D. Mougous
The paper investigates the midgut microbiome of Ixodes scapularis and finds it lacks a stable resident microbiota, which may explain the absence of interbacterial competition genes in Borrelia burgdorferi.
bioRxiv · Oct 4, 2017Microbiology