Author

E. B. Lee

University of Pennsylvania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pathology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Assay:imaging· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. C. McKee· 1 shared Andrea CorteseiD· 1 shared Andrea MalaspinaiD· 1 shared Anna‐Leigh BrowniD· 1 shared Avindra NathiD· 1 shared B. C. Creekmore· 1 shared B. E. Black· 1 shared Boya Zhang· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperPathology

A. C. McKee

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Author profile →

3 papers

Recent·Most cited

Native ultrastructure of fresh human brain vitrified directly from autopsy revealed by cryo-electron tomography with cryo-plasma focused ion beam milling

B. C. Creekmore, K. Kixmoeller, B. E. Black, E. B. Lee, Y.-W. Chang

This paper presents a method to image unfixed, never frozen human brain tissue using cryo-ET with xenon plasma FIB milling, revealing native ultrastructures like myelin and autophagy components.

bioRxiv · Sep 13, 2023 · PreprintPathology

Cell environment shapes TDP-43 function: implications in neuronal and muscle disease

Urša Šušnjar, Neva Škrabar, Anna‐Leigh Brown, Yasmine Abbassi, Hemali P. Phatnani, Pietro Fratta, Justin Y. Kwan, Dhruv Sareen, James Riley Broach, Zachary Simmons, Ximena Arcila-Londono, E. B. Lee, Vivianna M. Van Deerlin, Neil A. Shneider, Ernest Fraenkel, , Emanuele Buratti

The paper compares TDP-43's transcriptional and splicing effects in muscle and neuronal cells, showing tissue-specific roles in disease.

Communications Biology · Apr 5, 2022Peer-reviewedNeuroscience

Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study

M. A. Iida, K. Farrell, J. M. Walker, T. E. Richardson, G. Marx, C. H. Bryce, D. Purohit, G. Ayalon, T. G. Beach, E. H. Bigio, E. Cortes, M. Gearing, V. Haroutunian, C. T. McMillan, E. B. Lee, , J. F. Crary

This study identifies predictors of cognitive impairment in primary age-related tauopathy (PART) using autopsy data, finding that p-tau burden and cerebrovascular disease are significant predictors.

bioRxiv · Jun 8, 2021 · PreprintPathology