BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation
D. Edwards, R. Maganti, J. P. Tanksley, J. Luo, J. J. H. Park, E. Balkanska-Sinclair, J. Ling, S. R. Floyd
This study shows BET bromodomain inhibitors cause DNA damage by inducing R-loops and transcription-replication conflicts through impaired transcription elongation.
bioRxiv · Apr 13, 2020Cancer Biology