D. Edwards

Adaptive gene loss in the common bean pan-genome during range expansion and domestication

This study identifies adaptive gene loss in common bean populations during range expansion and domestication, showing gene loss as a key adaptive trait.

Comparative genomics of Japanese encephalitis virus shows low rates of recombination and a suite of sites under episodic diversifying selection

This study analyzes the genomic evolution of Japanese encephalitis virus, finding low recombination rates and episodic diversifying selection in specific proteins.

Genetic basis of expression and splicing underlying spike architecture in wheat (Triticum aestivum L.)

This study identifies eQTLs and sQTLs associated with spike architecture in wheat, revealing genetic factors that regulate gene expression and splicing related to yield traits.

Not all pathways are the same - unique adaptations to submerged environments emerge from comparative seagrass genomics

This study compares genome adaptations in two seagrass species, revealing lineage-specific changes in pathways related to salinity, disease resistance, and photosynthesis.

Rapid transmission and tight bottlenecks constrain the evolution of highly transmissible SARS-CoV-2 variants

The paper investigates the transmission bottlenecks of SARS-CoV-2 variants and finds that highly transmissible variants have tighter bottlenecks, limiting the spread of mutations.

Yield is negatively correlated with nucleotide-binding leucine-rich repeat gene content in soybean

This study finds a negative correlation between soybean yield and the number of nucleotide-binding leucine-rich repeat (NLR) resistance genes.

Brassica napus genes Rlm4 and Rlm7, conferring resistance to Leptosphaeria maculans, are alleles of the Rlm9 wall-associated kinase-like resistance locus

This paper identifies Rlm4 and Rlm7 as alleles of the Rlm9 resistance locus in Brassica napus, encoding WAKL proteins that confer resistance to Leptosphaeria maculans.

Haplotype mapping uncovers unexplored variation in wild and domesticated soybean at the major protein locus cqProt-003

This study maps haplotype variation at the cqProt-003 locus in soybean, identifying structural variants and tandem repeats associated with high protein content and tracing their distribution across wild, landrace, and cultivated populations.

Genomic rearrangements have consequences for introgression breeding as revealed by genome assemblies of wild and cultivated lentil species

The paper develops genome assemblies of wild and cultivated lentil species to reveal structural rearrangements affecting introgression breeding.

Suppression of sost/sclerostin and dickkopf-1 promote intervertebral disc structure in mice

This study shows that suppressing sclerostin or dkk1 promotes intervertebral disc structure by enhancing Wnt signaling, but sclerostin also reduces cellular stress pathways.

SARS-CoV-2 Vaccines Elicit Durable Immune Responses in Infant Rhesus Macaques

This study evaluates two SARS-CoV-2 vaccines in infant rhesus macaques, finding both induce durable antibody and T cell responses without adverse effects.

mRNA-1273 efficacy in a severe COVID-19 model: attenuated activation of pulmonary immune cells after challenge

This study evaluates mRNA-1273 vaccine efficacy in hamsters, showing reduced pulmonary immune activation and improved disease outcomes after prime-boost vaccination.

Linkage mapping and QTL analysis of flowering time using ddRAD sequencing with genotype error correction in Brassica napus

This study uses ddRAD sequencing with genotype error correction to map flowering time QTLs in Brassica napus, identifying a QTL on chromosome C2 near flowering time genes.

Evaluating aerosol and splatter following dental procedures: addressing new challenges for oral healthcare and rehabilitation

This study evaluates aerosol and splatter distribution from dental procedures using fluorescein and two analytical methods, finding contamination up to 4 meters with significant reduction via suction.

SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness

This paper describes the development of an mRNA vaccine (mRNA-1273) against SARS-CoV-2, showing it induces neutralizing antibodies and CD8 T cell responses and protects mice from infection.

Hypoxia driven oncometabolite L-2HG maintains "stemness"-differentiation balance and facilitates immune suppression in pancreatic cancer

This study shows hypoxia drives L-2HG production in pancreatic tumors, maintaining stemness-differentiation balance and promoting immune suppression, with LDH inhibition reversing these effects.

BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation

This study shows BET bromodomain inhibitors cause DNA damage by inducing R-loops and transcription-replication conflicts through impaired transcription elongation.

Speed breeding: a powerful tool to accelerate crop research and breeding

This paper introduces speed breeding, a method that accelerates crop research and breeding by shortening generation times and enabling more generations per year.