J. Ling

AARS Online: a collaborative database on the structure, function, and evolution of the aminoacyl-tRNA synthetases

AARS Online provides a curated database of aminoacyl-tRNA synthetases with sequence, structure, and evolutionary information, accessible via an interactive platform.

Integrating molecular and clinical variables to predict myocardial recovery

This study integrates clinical and transcriptomic data to predict myocardial recovery in heart failure patients after LVAD implantation, identifying 80 features with an AUC of 0.731.

Salmonella Typhimurium infection inhibits macrophage IFNbeta signaling in a TLR4-dependent manner

This study shows Salmonella Typhimurium inhibits macrophage IFNbeta signaling via TLR4, but IFNbeta does not affect host defense against STm.

Gentle rhodamines for live-cell fluorescence microscopy

This paper introduces Gentle Rhodamines with reduced phototoxicity for live-cell imaging, enabling time-lapse and voltage imaging with less cellular damage.

Enhancing mitochondrial pyruvate metabolism ameliorates myocardial ischemic reperfusion injury.

This study shows that inhibiting MCT4 to redirect pyruvate metabolism reduces myocardial ischemia-reperfusion injury by improving mitochondrial function and reducing oxidative stress.

Deficiency in ribosome biogenesis causes streptomycin resistance and impairs motility in Salmonella

This study identifies RimP as a ribosome assembly factor in Salmonella that contributes to streptomycin resistance and motility impairment.

BBQ methods: Streamlined workflows for Bacterial Burden Quantification in infected cells by confocal microscopy

This paper introduces two automated methods for quantifying bacterial burden in macrophages using confocal microscopy, validated with Salmonella and Mycobacterium models.

A human urothelial microtissue model reveals shared colonization and survival strategies between uropathogens and asymptomatic bacteria

A human urothelial microtissue model identifies shared and distinct colonization strategies between uropathogens and asymptomatic bacteria, revealing pathogen-specific host responses.

MYPT1 is a non-canonical AKAP that tethers PKA to the MLCP signaling node

This study identifies MYPT1 as a non-canonical AKAP that directly interacts with PKA-R variants to tether PKA to the MLCP signaling node.

Higher habitual FODMAP intake is associated with lower body mass index, lower insulin resistance and higher short-chain fatty acid-producing microbiota in people with prediabetes

This study finds that higher habitual FODMAP intake in prediabetic individuals is linked to lower BMI, reduced insulin resistance, and increased SCFA-producing gut bacteria.

Cancer-associated SMARCAL1 loss-of-function mutations promote alternative lengthening of telomeres and tumorigenesis in telomerase-negative glioblastoma cells

This study shows SMARCAL1 loss-of-function mutations enable ALT in telomerase-negative glioblastoma cells, promoting tumorigenesis and telomere maintenance.

Structures of chloramphenicol acetyltransferase III and E. coli β-ketoacylsynthase III co-crystallized with partially hydrolysed acetyl-oxa(dethia)CoA

The paper presents structures of two enzymes bound to an acetyl-CoA analog, revealing differences in their interaction with the analog and providing insights into their catalytic mechanisms.

Cardiac patch treatment alleviates ischemic cardiomyopathy correlated with reverting Piezo1/2 expression by unloading left ventricular myocardium

This study shows cardiac patches reduce ischemic cardiomyopathy by lowering mechanical load and reverting Piezo1/2 expression in the left ventricle.

Discovery of a novel coronavirus in Swedish bank voles (Myodes glareolus)

The paper identifies a novel coronavirus in Swedish bank voles, showing repeated detection and phylogenetic placement in a divergent Embecovirus lineage.

Engineered chimeras unveil swappable modular features of fatty acid and polyketide synthase acyl carrier proteins

This study designs chimeric acyl carrier proteins to swap modular features between different ACPs, enabling compatibility with specific enzymes for synthetic pathway engineering.

Proliferative and quiescent human gastric cancer stem-like cells are associated with differential chemoresistance and patient mortality

This study identifies two stem-like gastric cancer subpopulations with distinct chemoresistance and survival outcomes using scRNA-seq and organoid models.

Suboptimal intermediates underlie evolution of the Bicoid homeodomain

The paper shows that suboptimal intermediates in the evolution of the Bicoid homeodomain enabled further evolutionary changes through epistatic interactions.

Antigen-specific induction of CD4+CD8αα+ intraepithelial T lymphocytes byBacteroidetes species

This study identifies Bacteroidetes species that induce CD4+CD8αα+ intraepithelial T lymphocytes, which provide protective immunity against colitis.

Circumpolar diversification of the Ixodes uriae tick virome

This study identifies RNA viruses in Ixodes uriae ticks from both hemispheres, finding shared viruses suggesting cross-circumpolar dispersal via migratory birds, while host populations remain geographically distinct.

Trade-Offs between Speed, Accuracy, and Dissipation in tRNAIle Aminoacylation

This study uses a stochastic model to analyze how tRNAIle aminoacylation balances speed, accuracy, and energy dissipation in E. coli, revealing an economic proofreading strategy that optimizes performance under tolerable error rates.

BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation

This study shows BET bromodomain inhibitors cause DNA damage by inducing R-loops and transcription-replication conflicts through impaired transcription elongation.

A nanobody that recognizes a 14-residue peptide epitope in the E2 ubiquitin-conjugating enzyme UBC6e modulates its activity

The paper identifies a nanobody that binds to a 14-residue epitope on UBC6e, enhancing its enzymatic activity and inhibiting phosphorylation in response to cell stress.

Increased Mistranslation Protects E. coli from Protein Misfolding Stress due to Activation of a RpoS-dependent Heat Shock Response

This study shows that increased mistranslation in E. coli enhances heat shock response via RpoS-dependent RpoH activation, protecting against protein misfolding stress.