Mono-phosphorylation at Ser4 of Barrier-to-autointegration Factor (Banf1) significantly reduces its DNA binding capability by inducing critical changes in its local conformation and DNA binding surface
M. Tang, A. Suraweera, X. Nie, Z. Li, J. Wells, K. O'Byrne, R. Woods, E. Bolderson, D. J. Richard
This study investigates how mono-phosphorylation at Ser4 of Banf1 disrupts its DNA binding by altering its conformation and binding surface through molecular modeling and simulations.
bioRxiv · May 21, 2023Biochemistry