J. Wells

Mono-phosphorylation at Ser4 of Barrier-to-autointegration Factor (Banf1) significantly reduces its DNA binding capability by inducing critical changes in its local conformation and DNA binding surface

This study investigates how mono-phosphorylation at Ser4 of Banf1 disrupts its DNA binding by altering its conformation and binding surface through molecular modeling and simulations.

Viral pIC-pocketing: RSV sequestration of eIF4F Initiation Complexes into bi-phasic biomolecular condensates

This study identifies a mechanism by which RSV sequesters eIF4F initiation complex components into bi-phasic inclusion bodies to facilitate viral mRNA translation.

A Pillar and Perfusion Plate Platform for Robust Human Organoid Culture and Analysis

This paper introduces a microarray 3D bioprinting platform with pillar and perfusion plates for high-throughput human organoid culture and analysis.

RAD18 opposes transcription-associated genome instability through FANCD2 recruitment

This study shows RAD18 recruits FANCD2 to suppress R-loops and transcription-replication conflicts, reducing genome instability during DNA replication stress.

Birnaviridae virus factories show features of liquid-liquid phase separation, and are distinct from paracrystalline arrays of virions observed by electron microscopy

The paper identifies Birnaviridae virus factories as non-membrane-bound structures with liquid-liquid phase separation properties, distinct from paracrystalline virion arrays.

Foot-and-mouth disease virus localisation on follicular dendritic cells and sustained induction of neutralising antibodies is dependent on binding to complement receptors (CR2/CR1)

This study shows FMDV binds to follicular dendritic cells via CR2/CR1, leading to sustained neutralising antibody responses in mice.

Using Community Science to Reveal the Global Chemogeography of River Metabolomes

This study uses community science to analyze global river metabolomes, revealing differences between surface water and sediment and significant spatial variation in sediment metabolites.

Disturbance Triggers Non-Linear Microbe-Environment Feedbacks

The paper tests a conceptual framework linking microbial communities with environmental factors and processes, finding non-linear feedbacks triggered by disturbance.

PEA polymer-coated nanotopography delivers solid-state BMP2, enhances mesenchymal stem cell adhesion, prevents bacterial biofilm formation and protects cells from quorum sensing virulence factors

Nanovibrational stimulation of mesenchymal stem cells induces therapeutic reactive oxygen species and inflammation for 3D bone tissue engineering

This study shows that nanovibrational stimulation of MSCs induces ROS and low-level inflammation, mimicking natural bone healing, and uses this to design a 3D bone tissue scaffold.

An emergent clade of SARS-CoV-2 linked to returned travellers from Iran

The paper identifies a distinct SARS-CoV-2 clade linked to travellers returning from Iran to Australia and New Zealand through whole genome sequencing and phylogenetic analysis.

The use of nanovibration to discover specific and potent bioactive metabolites that stimulate osteogenic differentiation in mesenchymal stem cells

This study uses nanovibration to induce osteogenic differentiation in MSCs without exogenous growth factors, identifying cholesterol sulphate and fludrocortisone acetate as potent bioactive metabolites.

Dissolved oxygen dynamics reveal biogeochemical tipping points driven by river corridor hydrology

The paper measures dissolved oxygen dynamics in a hydropeaked river system to identify hydrobiogeochemical tipping points driven by rapid hydrologic changes.

Carbon limitation leads to thermodynamic regulation of aerobic metabolism

The paper tests OM thermodynamics as a regulator of aerobic respiration, showing it dominates under carbon limitation and shifts to nitrogen content when carbon is in excess.

Discrete virus factories form in the cytoplasm of cells co-infected with two strains of the segmented dsRNA virus, infectious bursal disease virus (IBDV), that subsequently coalesce

This study tracks virus factory dynamics during co-infection of two IBDV strains, showing VFs coalesce later in infection, potentially enabling reassortment.

Nanotopography reveals metabolites that maintain the immunosuppressive phenotype of mesenchymal stem cells

This study shows nanotopography can control MSC immunomodulatory capacity by modulating intracellular tension and oxidative glycolysis, and identifies bioactive metabolites that influence MSC function.

Minimizing marine ingredients in diets of farmed Atlantic salmon (Salmo salar): Effects on growth performance and muscle lipid and fatty acid composition

This study evaluates the effects of reducing marine ingredients in Atlantic salmon diets on growth and muscle lipid composition, finding that low fish meal with moderate fish oil maintains omega-3 fatty acids and growth performance.