Genuine Selective Caspase-2 Inhibition with new Irreversible Small Peptidomimetics
E. Bosc, J. Anastasie, F. Soualmia, P. Coric, J. Y. Kim, G. Lacin, E. Duplus, P. Tixador, b. Brugg, M. Reboud-Ravaux, S. Bouaziz, M. Karin, C. El Amri, E. D. Jacotot
This paper develops and tests new irreversible peptidomimetics that selectively inhibit Caspase-2, showing efficacy in preventing cell death and synapse loss in disease models.
bioRxiv · Dec 13, 2021Pharmacology & Toxicology