J. Y. Kim

This study identifies a novel mechanism involving lysosomal Ca2+ release and K+ efflux through KCa3.1 channels in inflammasome activation and metabolic inflammation.

This study develops iMethyl, a method to estimate genomic hypomethylation from cell-free DNA to predict responses to immune checkpoint blockade in cancer patients.

This study addresses challenges in preparing Drosophila melanogaster neurons for cryo-ET by optimizing substrate selection, micropatterning, data collection, and fixation.

This study uses machine learning to guide high-throughput screening and discovers small molecules that modulate innate immune pathways, with some showing up to 15-fold suppression of NF-κB activity.

The paper validates a new ISS model for estimating insulin sensitivity and beta-cell function from OGTTs, showing strong correlation with gold-standard methods across diverse populations.

The paper shows that reducing mitochondrial pyruvate carrier activity in kidney tubular cells protects against acute kidney injury by enhancing redox defenses and survival.

This paper develops and tests new irreversible peptidomimetics that selectively inhibit Caspase-2, showing efficacy in preventing cell death and synapse loss in disease models.

This study identifies metabolic rewiring in mitochondria during cellular senescence through time-resolved proteomic analysis in human fibroblasts.

The paper introduces Q-SHINE, a sensor for measuring glutamine levels through ligand-induced dimerization, enabling accurate detection in bio-fluids and living cells.

This study compares the infectivity of SARS-CoV-2 variants in human alveolar cells, finding Omicron (BA.1) to be 3-5-fold more infectious than other variants at early infection.

This study identifies mutations and copy-number variations in breast tumorigenic cells and shows that ECM-mimetic platforms enhance their migration.

OncoLoop predicts and validates drug sensitivity in tumors and their models by leveraging perturbational profiles of oncology drugs, showing success in prostate cancer models and patient cohorts.

This paper introduces tools for montage electron tomography to improve imaging of large fields of view in cryo-electron tomography while maintaining high-resolution structural information.

The paper validates a neoantigen prediction algorithm, Neopepsee, by testing its immunogenicity using ELISpot assays on patient-derived samples and compares it to pVACseq.

This study uses cryo-electron tomography to show RSV matrix protein forms a helical lattice that positions the fusion glycoprotein, providing insights into virion organization and potential vaccine targets.

This paper demonstrates the use of micropatterning to culture and adhere eukaryotic cells on TEM grids for whole-cell cryo-ET, enhancing studies of cellular structures and host-pathogen interactions.

This study evaluates glycoproteomics software performance using human serum datasets, identifies high-performance strategies, and provides recommendations for improved analysis.

This study identifies off-target ferrochelatase inhibition as a mechanism of vemurafenib-induced nephrotoxicity in renal tubular epithelial cells.

The paper identifies VGF as a stress-responsive protective gene in kidney epithelial cells, showing that SOX9 drives its transcription during injury.

This study compares the microbiomes of three Periplaneta cockroach species using 16S rRNA sequencing, finding similar but distinct bacterial compositions despite shared rearing conditions.

The paper identifies a peptide coating that enhances nanoparticle diffusion through the tumor microenvironment by screening phage libraries and testing transport in vitro and ex vivo.