M. Karin

Disruptors of sestrin-MAPK interactions rejuvenate T cells and expand TCR specificity

This paper develops DOS, a first-in-class disruptor of sestrin-MAPK complexes, which rejuvenates senescent T cells and expands TCR specificity by generating new T cell clones.

Macrophage Xanthine Oxidoreductase Links LPS Induced Lung Inflammatory Injury to NLRP3 Inflammasome Expression and Mitochondrial Respiration

This study shows that macrophage-specific Xanthine Oxidoreductase (XOR) exacerbates LPS-induced lung injury by promoting NLRP3 inflammasome expression and glycolytic metabolism in inflammatory macrophages.

Angiotensin II receptor inhibition ameliorates liver fibrosis and enhances hepatocellular carcinoma infiltration by effector T cells

This study shows that losartan, an angiotensin II receptor inhibitor, reduces liver fibrosis and enhances T cell infiltration in HCC, improving response to PD-1 blockade.

IRF1 regulates self-renewal and stress-responsiveness to support hematopoietic stem cell maintenance

This study identifies IRF1 as a master regulator of hematopoietic stem cell (HSC) self-renewal and stress responses, showing its role in maintaining HSC function and its relevance in AML patient stratification.

Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice

This study shows that lactational exposure to Triclosan in mice causes fatty liver disease by disrupting metabolic pathways involving PERK-eIF2-ATF4-PPAR.

Collagen remodeling dictates pancreatic cancer bioenergetics and outcome through DDR1 activation or degradation

This study shows that collagen remodeling via MMP cleavage affects pancreatic cancer bioenergetics and outcome through DDR1 activation or degradation, with distinct impacts on tumor growth and survival.

Single Nucleus RNA Sequencing of Pre-Malignant Liver Reveals Disease-Associated Hepatocyte State with HCC Prognostic Potential

The paper uses snRNA-seq to identify a disease-associated hepatocyte state in pre-malignant livers that correlates with HCC risk in mice and humans.

Genuine Selective Caspase-2 Inhibition with new Irreversible Small Peptidomimetics

This paper develops and tests new irreversible peptidomimetics that selectively inhibit Caspase-2, showing efficacy in preventing cell death and synapse loss in disease models.

Intercellular telomere transfer extends T cell lifespan

The paper shows T cells extend telomeres by acquiring telomere vesicles from APCs, independent of telomerase, thereby increasing their lifespan.