Pharmacology & ToxicologybioRxiv
Genuine Selective Caspase-2 Inhibition with new Irreversible Small Peptidomimetics
E. Bosc, J. Anastasie, F. Soualmia…·E. D. Jacotot
This paper develops and tests new irreversible peptidomimetics that selectively inhibit Caspase-2, showing efficacy in preventing cell death and synapse loss in disease models.
DOI 10.1038/s41419-022-05396-2