Single Nucleus RNA Sequencing of Pre-Malignant Liver Reveals Disease-Associated Hepatocyte State with HCC Prognostic Potential
R. Carlessi, E. Denisenko, E. Boslem, J. Koehn-Gaone, N. Main, N. D. B. A. Bakar, G. D. Shirolkar, M. Jones, D. Poppe, B. J. Dwyer, C. Jackaman, M. C. Tjiam, R. Lister, M. Karin, J. A. Fallowfield, , J. E. E. Tirnitz-Parker
The paper uses snRNA-seq to identify a disease-associated hepatocyte state in pre-malignant livers that correlates with HCC risk in mice and humans.
bioRxiv · Mar 25, 2022Cancer Biology