Simple visualization of submicroscopic protein clusters with a phase-separation-based fluorescent reporter.
T. R. Mumford, D. Rae, E. Brackhahn, A. Idris, D. Gonzalez-Martinez, A. A. Pal, M. C. Chung, J. Guan, E. Rhoades, L. J. Bugaj
This paper introduces CluMPS, a fluorescent reporter that detects and amplifies submicroscopic protein clusters, enabling visualization of small oligomers and endogenous protein assemblies.
bioRxiv · Jul 13, 2022Bioengineering