Stepwise recruitment of Hsc70 by DNAJB1 produces ordered arrays primed for bursts of amyloid fibre disassembly
J. Monistrol, J. G. Beton, E. C. Johnston, H. Saibil
This study shows DNAJB1 recruits Hsc70 in two steps to amyloid fibers, forming ordered arrays that enable efficient disaggregation, while a mutant disrupts this organization.
bioRxiv · Jan 25, 2024 · PreprintBiochemistry