H. R. Saibil

The paper uses cryoEM to determine structures of GroEL-GroES complexes with Rubisco, revealing conformational changes and interactions during the chaperonin cycle.

This study identifies the sequential roles of DBP and NBPXa in P. knowlesi merozoite invasion of human RBCs, revealing a phased commitment mechanism that can be targeted with antibodies.

This paper determines the cryo-EM structure of ME7 prion fibrils and compares it to RML fibrils, revealing structural differences that explain prion strain diversity within the same species.

The paper presents a cryo-EM structure of prion fibrils from RML prion-infected mice, revealing structural features and conformational variations that may influence prion strain diversity and propagation.

The paper shows that Hsc70 and DNAJB1, with Apg2, cooperatively bind and disassemble amyloid fibrils, with Apg2 enhancing Hsc70 recruitment and disassembly rate.

This study presents a high-resolution cryo-EM structure of the perforin pore, revealing conformational changes and interactions that explain its function and pathogenic mutations.