Author

B. Bukau

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:protein folding & dynamics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Approach:wet-lab / biochemical assay· 2 Organism:bacteria (other)· 1 Organism:C. elegans· 1

Frequent Co-Authors

G. Kramer· 2 shared A. J. Roberts· 1 shared A. Mogk· 1 shared A. S. Wentink· 1 shared A. Wentink· 1 shared B. W. Hoogenboom· 1 shared C. A. Sandhof· 1 shared C. Nussbaum-Krammer· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersBiochemistry

G. Kramer

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Author profile →

5 papers

Recent·Most cited

A unique chaperoning mechanism in Class A JDPs recognizes and stabilizes mutant p53.

G. Zoltsman, T. L. Dang, M. Kuchersky, O. Faust, M. S. Silva, T. Ilani, A. S. Wentink, B. Bukau, R. Rosenzweig

This study identifies a unique chaperoning mechanism in class-A JDPs that recognizes and stabilizes mutant p53, promoting cancer progression by preventing its degradation.

bioRxiv · Nov 28, 2023Biochemistry

Translational Activity Controls Ribophagic Flux and Turnover of Distinct Ribosome Pools

J. Trendel, M. Aleksic, M. Bertolini, M. Jochem, G. Kramer, S. Pfeffer, B. Bukau, J. Krijgsveld

The paper investigates ribosome turnover in human cells, showing distinct subunit pools with different turnover rates and demonstrating that translation inhibition increases 80S ribosome pool size and induces ribophagy.

bioRxiv · May 13, 2022 · PreprintBiochemistry

Cooperative Amyloid Fibre Binding and Disassembly by the Hsp70 disaggregase

J. G. Beton, J. Monistrol, A. Wentink, E. C. Johnston, A. J. Roberts, B. Bukau, B. W. Hoogenboom, H. R. Saibil

The paper shows that Hsc70 and DNAJB1, with Apg2, cooperatively bind and disassemble amyloid fibrils, with Apg2 enhancing Hsc70 recruitment and disassembly rate.

bioRxiv · Aug 29, 2021Biochemistry

HSP110 dependent HSP70 disaggregation machinery mediates prion-like propagation of amyloidogenic proteins in metazoa

J. Tittelmeier, C. A. Sandhof, H. M. Ries, S. Druffel-Augustin, A. Mogk, B. Bukau, C. Nussbaum-Krammer

This study shows that HSP110-dependent HSP70 disaggregation machinery both maintains proteostasis and promotes prion-like propagation of amyloidogenic proteins in metazoa.

bioRxiv · Oct 9, 2019Cell Biology

The C-terminal tail of the bacterial translocation ATPase SecA modulates its activity

M. Jamshad, T. Knowles, S. White, D. Ward, F. Mohammed, K. F. Rahman, G. W. Hughes, G. Kramer, B. Bukau, D. Huber

This study investigates how the C-terminal tail of SecA modulates its activity in cotranslational substrate protein recognition by interacting with ribosomes and substrate proteins.

bioRxiv · Aug 22, 2018Biochemistry