J. Martin

Human chronic inflammation is orchestrated by spatially restricted inflammation-activated Dendritic cells

This study identifies a novel inflammation-associated dendritic cell state in human chronic inflammation and shows its spatial restriction and therapeutic relevance.

R6G narrows BmrA conformational spectrum for a more efficient use of ATP

This study shows that Rhodamine6G binding to BmrA narrows its conformational spectrum, enhancing ATP-dependent transport efficiency.

Identification of novel Bromodomain inhibitors of Trypanosoma cruzi Bromodomain Factor 2 (TcBDF2) using a fluorescence polarization-base high-throughput assay

The paper develops a fluorescence polarization-based assay to identify bromodomain inhibitors of TcBDF2, finding 7 novel compounds that bind TcBDF2 with dissociation constants between 1 and 3 M.

The relationship between gut and nasopharyngeal microbiome composition can predict the severity of COVID-19

The paper identifies microbiome biomarkers and a gut-nasopharyngeal microbiota ratio that predict severe COVID-19 outcomes.

The dynamics of protein-RNA interfaces using all-atom molecular dynamics simulations

This study uses all-atom molecular dynamics simulations to analyze the dynamics of protein-RNA interfaces, revealing structural rearrangements and alternative residue-residue contacts.

Butyrate-producing bacteria as probiotic supplement: beneficial effects on metabolism and modulation of behavior in an obesity mouse model

This study tests the effects of four butyrate-producing bacteria on obesity and behavior in mice, finding one strain reduces obesity complications.

Lipid discovery enabled by sequence statistics and machine learning

The paper uses sequence data and machine learning to identify novel substrates and lipid products of MprF in bacteria.

Multi-modal profiling of biostabilized human skin modules reveals a coordinated ecosystem response to injected mRNA-1273 COVID-19 vaccine.

This study uses VaxSkin to analyze the skin's response to mRNA-1273 vaccine, showing targeted immune cell activation and communication.

Full-length direct RNA sequencing uncovers stress-granule dependent RNA decay upon cellular stress

This study uses direct RNA sequencing to show that cellular stress causes widespread 5' end RNA decay linked to stress granules, independent of deadenylation or decapping.

Establishment of a screening platform based on human coronavirus OC43 for the identification of microbial natural products with antiviral activity

This paper establishes a high-throughput screening platform using HCoV-OC43 to identify microbial natural products with antiviral activity, identifying 10 extracts with potential new compounds and confirming antiviral activity in others.

Kinetic stabilization of translation-repression condensates by a neuron-specific microexon

The paper shows that a neuron-specific microexon in CPEB4 stabilizes translation-repression condensates by competing with aggregation, enabling reversible regulation of gene expression in neurons.

Production of antigenically stable enterovirus A71 virus-like particles in Pichia pastoris as a vaccine candidate.

This study produces antigenically stable EVA71 virus-like particles in Pichia pastoris, showing they retain native antigenic conformation and elicit neutralising antibodies comparable to inactivated virus vaccines.

Two conformations of the Tom20 preprotein receptor in the TOM holo complex

The paper determines the structure of the TOM holo complex from Neurospora crassa, revealing two conformations of the Tom20 receptor and its role in guiding precursor proteins into mitochondria.

Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis

This study investigates the mechanism of vedolizumab in ulcerative colitis by analyzing immune cell changes in gut-associated lymphoid tissue and shows that targeting GALT is a novel mechanism of action.

3-D deconvolution of human skin immune architecture with Multiplex Annotated Tissue Imaging System (MANTIS)

This paper introduces MANTIS, a tool for 3-D deconvolution of human skin immune architecture, revealing common immune features in severe skin conditions.

Internal Normal Mode Analysis applied to RNA flexibility and conformational changes

This study applies internal normal mode analysis to RNA to predict flexibility and conformational changes, showing its effectiveness despite simplifications.

Ceramide synthase 6 (CerS6) promotes alcohol-induced fatty liver by promoting metabolic dysfunction and upregulating lipid droplet-associated proteins

This study shows that deleting CerS6 reduces alcohol-induced fatty liver and improves glucose homeostasis in mice, and links CerS6 expression to ALD progression in humans.

We the Hunted

The paper reclassifies the SK 54 cranium as Homo erectus, challenging the hypothesis that Homo was better at avoiding predation than Paranthropus.

Morphological Differences in Isolated Brook Trout Populations in the Desolation Wilderness of the Sierra Nevada

The paper quantifies morphological differences among three isolated brook trout populations in the Sierra Nevada, showing physical variation despite common origin.

The immunodominant protein P116 extracts cholesterol and other essential lipids

This paper identifies P116 as a lipid-extracting protein from Mycoplasma pneumoniae, revealing its structural mechanism for extracting cholesterol and other lipids from host environments.

Modulation of the gut microbiome by novel synthetic glycans for the production of propionate and the reduction of cardiometabolic risk factors

This paper identifies a synthetic glycan, KB39, that increases propionate production by the gut microbiome and reduces cardiometabolic risk factors in mice.

Single-Cell Atlas of Common Variable Immunodeficiency reveals germinal center-associated epigenetic dysregulation in B cell responses

The paper creates a single-cell atlas of CVID, identifying epigenetic and transcriptional defects in memory B cells and linking them to impaired cell communication.

Collinearity of alpha-helices or beta strands in membrane proteins causes a characteristic peak centred on 4.9 A resolution in diffraction intensity profiles, inducing higher diffraction anisotropy

Bromodomain factor 5 is an essential transcriptional regulator of the Leishmania genome.

This study identifies BDF5 as essential for Leishmania gene expression and survival by analyzing its role in chromatin interpretation and transcriptional regulation.

Identification of the 216kbp gene cluster and structure elucidation of gargantulides B and C, new complex 52-membered macrolides from Amycolatopsis sp.

This study identifies a 216 kbp gene cluster and elucidates the structures of gargantulides B and C, new 52-membered macrolides from Amycolatopsis sp., revealing their biosynthetic pathway and antibacterial activity.

Isolation and characterization of a novel Wolbachia bacteriophage from Allonemobius socius crickets in Missouri

The paper isolates and characterizes a novel Wolbachia bacteriophage from crickets in Missouri, providing the first whole-genome sequence of phage WO from this species outside Asia.

Increasing role of pyrethroid-resistant Anopheles funestus in malaria transmission in the Lake Zone, Tanzania: implications for the evaluation of novel vector control products

The paper examines the increasing role of pyrethroid-resistant Anopheles funestus in malaria transmission in Tanzania and highlights the need for new vector control tools.

Drug-bound and -free outward-facing structures of a multidrug ABC exporter point to a swing mechanism

The paper resolves two ATP-Mg2+-bound outward-facing conformations of BmrA, revealing a swing mechanism for drug transport through structural and dynamic analyses.

Discovery of photosynthesis genes through whole-genome sequencing of acetate-requiring mutants of Chlamydomonas reinhardtii

The paper sequenced genomes of photosynthesis mutants in Chlamydomonas reinhardtii to identify candidate genes involved in photosynthesis, validating two essential genes and uncovering 273 high-confidence candidates.

Genomic and phenotypic characterization of experimentally selected resistant Leishmania donovani reveals a role for dynamin-1 like protein in the mechanism of resistance to a novel anti-leishmanial compound

This study experimentally selects resistance to a novel anti-leishmanial compound in Leishmania donovani and identifies mutations in the dynamin-1-like protein as a key mechanism of resistance.