BET protein inhibition regulates macrophage chromatin accessibility and microbiota-dependent colitis
M. Hoffner O'Connor, A. Berglind, M. M. Kennedy, B. P. Keith, Z. J. Lynch, M. R. Schaner, E. C. Steinbach, J. Herzog, O. K. Trad, W. R. Jeck, J. C. Arthur, R. B. Sartor, T. Furey, S. Z. Sheikh
This study shows that BET protein inhibition reduces macrophage inflammation and colitis severity by altering chromatin accessibility and gene expression.
bioRxiv · Jul 15, 2021 · PreprintImmunology