M. T. Ferris

The paper infects diverse mouse strains with a hepacivirus and shows host genetic variation influences viral clearance, chronicity, and liver fibrosis outcomes.

This study identifies host genetic factors influencing POWV pathogenesis in CC mice, showing resistance correlates with reduced viral replication and brain infection.

The paper identifies a multitrait locus on mouse Chromosome 9 that regulates SARS-CoV, SARS-CoV-2, and bat sarbecovirus disease severity, with candidate genes CCR9 and CXCR6.

This study identifies Zhx2 as a candidate gene influencing oxymorphone brain concentrations and state-dependent oxycodone reward in female mice.

The paper identifies Angptl4 as a biomarker of peanut allergy by showing increased intestinal permeability and serum Angptl4 levels in a mouse model and pediatric patients.

The paper identifies host susceptibility loci for SARS-CoV and SARS-CoV-2 using GWAS and Collaborative Cross datasets, validating CCR9 as a key regulator of severe disease outcomes across species.

The paper shows that baseline T cell immune signatures in mice predict virologic and disease outcomes upon SARS-CoV infection.

This study identifies Muc4 as a protective factor in female mice against SARS-CoV pathogenesis, showing sex-specific effects without altering viral titers.

The paper identifies multiple genetic loci associated with tuberculosis susceptibility in Collaborative Cross mice, including a loss-of-function mutation in Itgal that impairs T cell recruitment.

The paper tests Collaborative Cross mice as an immune-competent model for ZIKV infection, finding poor infection and low antibody response.