Replenishing the malaria drug discovery pipeline: Screening and hit evaluation of the MMV Hit Generation Library 1 (HGL1) against asexual blood stage Plasmodium falciparum, using a nano luciferase reporter read-out
K. J. Dechering, M. Timmerman, K. Rensen, K. M. J. Koolen, S. Honarnejad, M. Vos, T. Huijs, R. Henderson, E. Chenu, B. Laleu, B. C. Montefiore, M. D. Segall, J. E. J. Mills, E. M. Guantai, J. Duffy, M. Duffey
The paper screens a compound library against Plasmodium falciparum using a nanoluciferase assay, identifying 33 high-quality hits for antimalarial drug development.
bioRxiv · Jun 7, 2022Microbiology