R. Henderson

SARS-CoV-2 Omicron XBB lineage spike structures, conformations, antigenicity, and receptor recognition

The paper determines cryo-EM structures of SARS-CoV-2 XBB lineage spike proteins, revealing structural changes that enhance immune evasion and receptor binding.

Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination in nonhuman primates

Non-stabilized SARS-CoV-2 Spike mRNA vaccination in macaques induces B cell lineages targeting conserved epitopes on Omicron variants or cross-neutralizing epitopes on Sarbecoviruses.

Engineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies

This study uses molecular dynamics simulations to design HIV-1 immunogens that select for specific mutations in broadly neutralizing antibodies.

Microsecond dynamics control the HIV-1 envelope conformation

This study uses time-resolved scattering to observe microsecond dynamics in HIV-1 Env, revealing rapid transitions that conventional strategies may not address.

Vaccine induction of CD4-mimicking broadly neutralizing antibody precursors in macaques

This study shows that vaccinating macaques with a CD4bs-targeting immunogen elicits neutralizing bnAb precursors with structural features of CD4-mimicking antibodies.

Mutation-Guided Vaccine Design: A Strategy for Developing Boosting Immunogens for HIV Broadly Neutralizing Antibody Induction

The paper demonstrates a mutation-guided vaccine strategy that induces HIV broadly neutralizing antibodies in mice by selecting for rare B cell lineage mutations.

Structural basis for breadth development in a HIV-1 neutralizing antibody

This paper determines structures of HIV-1 antibodies at different stages of maturation to understand how neutralization breadth develops through affinity optimization.

Replenishing the malaria drug discovery pipeline: Screening and hit evaluation of the MMV Hit Generation Library 1 (HGL1) against asexual blood stage Plasmodium falciparum, using a nano luciferase reporter read-out

The paper screens a compound library against Plasmodium falciparum using a nanoluciferase assay, identifying 33 high-quality hits for antimalarial drug development.

Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike

This study determines cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike and compares them to BA.1, revealing structural changes and immune evasion mechanisms.

Structural diversity of the SARS-CoV-2 Omicron spike

The paper compares cryo-EM structures of SARS-CoV-2 Omicron and Delta spikes to analyze conformational changes affecting immune evasion and transmissibility.

The use of barcoded Asaia bacteria in mosquito in vivo screens for identification of systemic insecticides and inhibitors of malaria transmission

This paper develops a barcoding strategy using Asaia bacteria to screen for systemic insecticides and malaria transmission inhibitors in mosquitoes.

Ability of nucleoside-modified mRNA to encode HIV-1 envelope trimer nanoparticles

This study shows that nucleoside-modified mRNA can encode HIV-1 Env trimer nanoparticles that induce bnAb precursor B cell expansion and neutralizing activity in mice.

Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183

This paper characterizes MMV693183, a novel antimalarial compound targeting acetyl-CoA synthetase, showing in vitro and in vivo efficacy against Plasmodium species and transmission blocking.

Effect of natural mutations of SARS-CoV-2 on spike structure, conformation and antigenicity

This study examines how mutations in SARS-CoV-2 spike protein affect its structure, conformation, and antigenicity across variants from different origins.

Defocus-dependent Thon-ring fading

This paper explains defocus-dependent Thon-ring fading in electron cryo-microscopy and shows that higher defocus values can be safely used.

D614G mutation alters SARS-CoV-2 spike conformational dynamics and protease cleavage susceptibility at the S1/S2 junction

This study shows the D614G mutation in SARS-CoV-2 spike protein increases furin cleavage efficiency and alters RBD dynamics through allosteric effects.

Cold sensitivity of the SARS-CoV-2 spike ectodomain

The paper shows that the SARS-CoV-2 spike ectodomain construct 2P is cold-sensitive, and this sensitivity is resolved in a down-state stabilized spike.

A glycan cluster on the SARS-CoV-2 spike ectodomain is recognized by Fab-dimerized glycan-reactive antibodies

The paper shows that HIV-1 broadly neutralizing antibodies recognize a glycan cluster on the SARS-CoV-2 spike protein, revealing a potential target for vaccine design.

Fab-dimerized glycan-reactive antibodies neutralize HIV and are prevalent in humans and rhesus macaques

The paper identifies Fab-dimerized glycan-reactive antibodies in HIV-infected macaques and HIV-naïve humans that neutralize HIV-1 and can be elicited by vaccination.

Glycans on the SARS-CoV-2 Spike Control the Receptor Binding Domain Conformation

The paper shows glycans on SARS-CoV-2 Spike influence RBD conformational states, affecting antibody neutralization and vaccine design.

Controlling the SARS-CoV-2 Spike Glycoprotein Conformation

The paper analyzes SARS-CoV-2 spike protein conformations and develops engineered constructs to control its mobility for vaccine design.

Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements

This study identifies a critical role for W571 in HIV-1 Env allostery by showing mutations disrupting CD4-induced rearrangements and rendering Env insensitive to CD4 binding.