Adipocyte vesicles: ‘all-in-one’ packages that stimulate tumor mitochondrial metabolism and dynamics
E. Clement, I. Lazar, C. Attane, L. Carrie, S. Dauvillier, M. Ducoux-Petit, T. Menneteau, M. Moutahir, S. Le Gonidec, S. Dalle, P. Valet, O. Schiltz, C. Muller, L. Nieto
This study shows adipocyte extracellular vesicles enhance melanoma fatty acid oxidation and migration via lipid droplet-stored fatty acids, with obesity amplifying this effect through increased fatty acid transport.
bioRxiv · May 26, 2019 · PreprintCancer Biology