Author

E. Darbo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

F. Chibon· 2 shared G. Perot· 2 shared J.-Y. Blay· 2 shared L. Darmusey· 2 shared L. Gaston· 2 shared L. Leroy· 2 shared N. Desplat· 2 shared N. Thebault· 2 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

F. Chibon

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Distinct cellular origins and differentiation process account for distinct oncogenic and clinical behaviors of leiomyosarcomas

E. Darbo, G. Perot, L. Darmusey, S. Le Guellec, L. Leroy, L. Gaston, N. Desplat, N. Thebault, C. Merle, P. Rochaix, T. Valentin, G. Ferron, C. Chevreau, B. Bui, E. Stoeckle, , F. Chibon

The paper identifies a transcriptionally homogeneous subgroup of leiomyosarcomas originating from vascular smooth muscle cells and explains their unique oncogenic behavior through specific pathway alterations.

bioRxiv · Oct 23, 2020Cancer Biology

ATRX alteration contributes to tumor growth and immune escape in pleomorphic sarcomas

L. Darmusey, G. Perot, N. Thebault, S. Le Guellec, N. Desplat, L. Gaston, L. Delespaul, T. Lesluyes, E. Darbo, A. Gomez-Brouchet, E. Richard, J. Baud, L. Leroy, J. M. Coindre, J.-Y. Blay, F. Chibon

This study shows ATRX mutations in sarcomas promote tumor growth and immune escape by reducing mast cell immunity, suggesting targeting the innate immune system could improve outcomes.

bioRxiv · Oct 23, 2020Cancer Biology

Genome-Wide Reconstitution of Chromatin Transactions: RSC Preferentially disrupts H2A.Z-Containing Nucleosomes

A. Cakiroglu, C. Clapier, A. Ehrensberger, E. Darbo, B. Cairns, N. Luscombe, J. Svejstrup

The paper reconstitutes chromatin transactions in yeast by analyzing nucleosome stability and RSC preference for H2A.Z-containing nucleosomes.

bioRxiv · Aug 17, 2018Biochemistry