Author

F. Chibon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

G. Perot· 3 shared E. Darbo· 2 shared J.-Y. Blay· 2 shared L. Darmusey· 2 shared L. Gaston· 2 shared L. Leroy· 2 shared N. Desplat· 2 shared N. Thebault· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersCancer Biology

G. Perot

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Author profile →

3 papers

Recent·Most cited

A metabolic crosstalk between liposarcoma and muscle sustains tumor growth

G. Manteaux, J. Prieto Romero, L. Gayte, B. Riquier Morcant, A. Amsel, S. Jacq, M. Y. Cisse, G. Perot, F. Chibon, P. Pomies, N. Firmin, S. Carrere, R. Riscal, L. K. Linares

This study identifies IL-6 as a key mediator of metabolic crosstalk between liposarcoma and muscle, showing that blocking IL-6 reduces tumor growth.

bioRxiv · Jun 2, 2023 · PreprintCancer Biology

Distinct cellular origins and differentiation process account for distinct oncogenic and clinical behaviors of leiomyosarcomas

E. Darbo, G. Perot, L. Darmusey, S. Le Guellec, L. Leroy, L. Gaston, N. Desplat, N. Thebault, C. Merle, P. Rochaix, T. Valentin, G. Ferron, C. Chevreau, B. Bui, E. Stoeckle, , F. Chibon

The paper identifies a transcriptionally homogeneous subgroup of leiomyosarcomas originating from vascular smooth muscle cells and explains their unique oncogenic behavior through specific pathway alterations.

bioRxiv · Oct 23, 2020Cancer Biology

ATRX alteration contributes to tumor growth and immune escape in pleomorphic sarcomas

L. Darmusey, G. Perot, N. Thebault, S. Le Guellec, N. Desplat, L. Gaston, L. Delespaul, T. Lesluyes, E. Darbo, A. Gomez-Brouchet, E. Richard, J. Baud, L. Leroy, J. M. Coindre, J.-Y. Blay, F. Chibon

This study shows ATRX mutations in sarcomas promote tumor growth and immune escape by reducing mast cell immunity, suggesting targeting the innate immune system could improve outcomes.

bioRxiv · Oct 23, 2020Cancer Biology